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ScienceDirect (secondary analysis of two phase III trials) (2019) 6
Using a Drawing Needle For a truly professional technique, its best to use two separate needles: one for drawing the B12 from the vial and a new one for the injection itself
Optional: If the lysate is too viscous, add RNase A (10 g/mL) and DNase I (5 g/mL) and incubate on ice for 10-15 minutes
The short answer: there is promising but limited evidence
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