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Preclinical research published in The Lancet demonstrated that tirzepatide attenuated dopamine reward signaling and suppressed alcohol drinking and relapse-like behaviors in rodent models

The agency has identified some areas of concern for compounded GLP-1 drugs

Vaginal dryness and decreased lubrication When estrogen levels drop due to fat loss, the vaginal tissue can become thinner, less elastic, and less capable of producing adequate lubrication during arousal

Integrating coronary artery imaging and arrhythmic risk profiling may also refine risk stratification for SCD prevention

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