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However, rapid pharmacologically induced weight loss may be accompanied by unfavorable body-composition changes, including reductions in lean mass, and weight regain is common following treatment discontinuation, underscoring a major durability gap
Clinicians advise immediate medical evaluation and temporary discontinuation of GLP-1 therapy pending workup if pancreatitis is suspected
Weight loss varies depending on the individuals diet, lifestyle, and compliance
And a small randomized clinical trial found patients with opioid use disorder who took an older form of GLP-1 known as liraglutide experienced a 40 percent reduction in opioid cravings compared with a placebo
& Sobel, B
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