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N,N-dimethylphenethylamine is a GRAS flavoring additive that is very common in a variety of foods including cereal and generally safe when uses in low amounts as a flavor but safety has not been established at the high amounts used in supplements
The cardiovascular evidence is the most solid: in the SELECT trial, people with obesity and established heart disease who added semaglutide cut their risk of cardiovascular death, a second stroke, or a second heart attack by about 20%
USADA and other anti-doping organizations have spent years warning athletes about the potential legal and eligibility risks of using unapproved substances whether via prescription drugs or unvetted supplements while also articulating the health risks for elite athletes and others looking to gain a small advantage in the gym
But the signal is not landing
The gastrointestinal side effects common with GLP-1 receptor agonistsincluding nausea, diarrhea, constipation, and abdominal discomfortmay overlap with or potentially exacerbate symptoms related to altered bile flow after cholecystectomy
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