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It can express transcription factors Mac1 and Ctr1, which promote copper absorption, and can also avoid toxic effects caused by excessive copper accumulation through its unique plasma membrane structure and the activation of the copper resistance assay gene CRD1 [41,42,43,44,45]
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Besides the iron chelators mentioned above, there are also new iron chelators and other substances with iron-chelating properties under investigation
Side Effects & Safety Nausea 44% in STEP trials, most common side effect, dose-dependent Diarrhea 30% in trials Vomiting 24% in trials Constipation 24% in trials Stomach pain 20% in trials Pancreatitis rare but documented
Sci Rep 9 , 5360 (2019)
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