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This activity has been linked to TREM2 + macrophages, which become the dominant subset during the remission phase of MASH in mice (54)

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Similarly, a JAMA study found that patients using GLP-1 agonists for weight loss faced significantly higher risks of pancreatitis, gastroparesis, and bowel obstruction

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In a pivotal trial of 142 adult patients with progressing desmoid tumors not amenable to surgery, Ogsiveo elicited clinically meaningful and statistically significant improvement in the primary endpoint of progression-free survival compared to placebo