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The dose increases over time to move from a tolerability phase into a therapeutically active range
This agent DOES NOT cause low blood sugars or hypoglycemia
As mentioned in the study, administration of exenatide after SCI suppressed C/EBP homologous transcription factor protein (CHOP, a pro-apoptotic transcription factor central to ER stress-mediated apoptosis) while upregulating glucose regulatory protein 78 (GRP78, an ER chaperone with cytoprotective effects) in the injured spinal cord, leading to a significant decrease in tissue damage and a significant increase in oligodendrocyte progenitor cell survival [66]
What about hypoglycemia risk: Basaglar vs Ozempic
Altered cardiac myocyte Ca regulation in heart failure
