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By combining GLP-1, GIP, and glucagon receptor agonism, retatrutide simultaneously reduces energy intake, increases energy expenditure, and corrects insulin resistance and lipid flux

People with type 2 diabetes either have a decreased or absent incretin effect

(2024) specifically investigated the impact of GLP-1 agonists on diabetic foot ulcers and related complications, including lower limb amputation, DFU-related hospitalizations, and mortality

Blood-brain barrier The concept of the BBB can be traced back to the finding by Humphrey Ridley in 1695 [1, 2]