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Without human trials, clinicians cannot reliably determine appropriate dosing, long-term risks or whether benefits outweigh risks

They underscore not only the clinical impact of this drug class but also the urgent need to comprehensively review the evolving evidence base, clarify mechanistic insights, and explore future directions in both metabolic and non-metabolic disease contexts

& Abdul-Ghani, M

J Headache Pain 17(1):85 Scher AI, Stewart WF, Ricci JA, Lipton RB (2003) Factors associated with the onset and remission of chronic daily headache in a population-based study

Must have documented proof of health complications like ileus, gastroparesis, stomach paralysis, or gastrointestinal blockage