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Semaglutide has a half-life of approximately 7 days because it is structurally modified to resist DPP-4 degradation and bind to albumin in the blood, creating a slow-release reservoir
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* Correspondence: Fan Guo, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Thus, the dual role of GLP-1RAs in reducing neurodegeneration by improving neuronal survival and modulating microglial activity, providing a potential therapeutic approach for neurodegenerative diseases (summarized in Fig
ACS Sust Chem Eng (2023) 11:1598609
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