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Sitagliptin is a p-glycoprotein substrate, but does not inhibit p-glycoprotein mediated transport of digoxin

Its clinically proven to be effective and safer than alternative peptide therapies

For context, participants in the 12mg dose group lost an average of 71.2 pounds (32.3 kg) from a baseline weight of 248.5 pounds

this has contributed to acquiring a better physiological understanding of their metabolism in humans, while also highlighting the challenges and limitations of the current trials