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In March this year, the UKs National Institute for Health and Care Excellence (Nice) recommended its use for managing obesity

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If youve missed doses for more than 2 weeks : Call your doctor

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Substantial weight loss can increase the risk of cholelithiasis Exclude organic causes of obesity (e.g., hypothyr oid ism) before prescribing Orlistat Patients should be advised to adhere to dietary guidelines

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However, severe reactions such as difficulty breathing, facial swelling, and anaphylaxis occur in rare cases, indicating a serious allergic reaction that requires immediate medical attention

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In the placebo-controlled analyses for change in HbA 1c and change in body weight, we conducted a post hoc sensitivity analysis excluding one trial with a short duration (12 weeks) [18] and one trial that recruited participants on background insulin therapy [19]

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