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Furthermore, the clinical heterogeneity of PD, along with the absence of definitive diagnostic biomarkers in early stages, complicates patient stratification and endpoint definition in trials (see details in [15])

Comparative trials show that long-acting medications (exenatide once weekly, liraglutide, dulaglutide, and semaglutide) provide better glycemic control than short-acting medications (exenatide twice daily and lixisenatide) [90]

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