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Qualitative changes in the apolipoprotein concentrations also occur
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When your stores are low, all those things slow down and you feel low energy, weak, and just unwell
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In addition, in vitro studies have shown that recombinant TTR amyloid aggregates are internalized by human cardiac fibroblasts, which subsequently secrete IL-6 and IL-8, providing mechanistic evidence that TTR aggregates can trigger inflammatory responses in cardiac cells [77]
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