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Moreover, using probucol (500 mg/day, P.O for 6 months) for secondary prevention in patients with CHD lowered the incidence of the patients primary endpoint (cardiovascular disease death, hospitalization rate), which may be partly due to its strong antioxidant capacity [245]

Before we investigated the effects of TAT-DAT NT in SHR rats, we hoped to rule out the possibility that TAT-DAT NT may act differently in rats compare to mice

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This is likely due to the fact that MT-1 has a much shorter half-life than MT-2 at around 1 hour and its effects are much more short-lived