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However, greater weight gain has been observed in children treated with GLP-1RA shortly after discontinuation of treatment, compared to placebo (4)
Conservation makes sense for maintenance
is primarily supported by Wellcome (106262/Z/14/Z and 106263/Z/14/Z) and MRC-UK (MRC_MC_UU_12012/3) funding
Reassess total daily insulin dose at 12 weeks on maintenance semaglutide Many patients reduce insulin by 40 to 60% total Some patients discontinue insulin if A1C is at goal (typically below 7%) and glucose is stable Recheck A1C at 3 months to confirm glycemic control Hypoglycemia response: If glucose drops below 54 mg/dL (severe hypoglycemia threshold), treat immediately with 15 grams fast-acting carbohydrate, recheck in 15 minutes, and contact your provider the same day to discuss further insulin reduction
