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It improves insulin sensitivity, reduces hepatic glucose production, and has a favourable safety profile with low hypoglycaemia risk
These measures focus on gentle skincare, environmental modifications, and monitoring for any progression of symptoms
Classic systemic-illness red flags
Do not press too hard
Five agonists that provide GLP-1 and glucagon receptor activity are in phase I/II of clinical development, of which only cotadutide and SAR425899 have shown substantial glycaemic efficacy
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