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Finally, further studies should clarify the molecular pathways involved and extend the one-time application (much like the engraftment of neural stem cells [16] or bone marrow stromal cells [17] into the lesion site) to the continuous application for the recovery of pre-existing spinal cord injury

However, because HGF/c-Met signaling also plays roles in cell proliferation and is implicated in certain cancers, the long-term safety implications of chronic c-Met activation require careful evaluation