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Patients with subclinical hypothyroidism or HT frequently have lower serum iron concentration and a higher prevalence of ID than do healthy controls ( Reference Erdal, Sahin and Hasimi 48 , Reference Nekrasova, Strongin and Ledentsova 49 )
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Given its essential role in the detoxification of lipid hydroperoxides, and its overexpression in most of myeloid malignancies, GPX4 inhibition has emerged as a promising therapeutic strategy to specifically trigger ferroptosis and eradicate myeloid leukemia cells