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It is also involved in immune function, metabolism, tissue building and repair, sperm cell formation, and certain enzyme functions
in terms of intervention strategies, the design of combination therapy should also revolve around the main line of PCDimmune microenvironment, for example, constructing mesenchymal stem cells or epithelial progenitor cells with anti-ferroptosis/anti-pyroptosis capabilities through gene editing or pre-treatment, enabling them to survive in a high oxidative stress lung environment and actively secrete IL-10, TGF-, or pro-resolving mediators, in combination with small molecule PCD modulators, thus achieving a combined effect of inhibiting destructive death programs + enhancing reparative immune programs within the same immunemetabolic framework
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Single nuclei transcriptomics delineates complex immune and kidney cell interactions contributing to kidney allograft fibrosis
L-citrulline is by definition, an amino acid largely present in kidneys, vascular endothelium, as well as other tissues, which can be converted into L-arginine, a study by S
