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Four arms: TRIUMPH-1 - chronic weight management in adults with obesity TRIUMPH-2 - chronic weight management in adults with type 2 diabetes plus obesity TRIUMPH-3 - chronic weight management in adults with cardiovascular disease and obesity TRIUMPH-4 - knee osteoarthritis in adults with obesity As of the date of this article retatrutide is not yet licensed as a medicine in any jurisdiction

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For multi-site or persistent cases: go with Glycopyrrolate 1% spray once daily