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In experimental systems, the combination is studied as a model for examining how complementary peptide signaling pathways influence tissue remodeling and cellular repair responses

For ROS measurement, cells were seeded into a 24-well plate at 3.5 10 4 cells per well and allowed to adhere overnight

If PLP is normal or low, investigate other causes including B12 deficiency, thiamine deficiency, or diabetes-related neuropathy