NICE guidance (NG145) recommends starting with a dose of 1.6 micrograms per kilogram of body weight per day in most adults, with lower starting doses (2550 micrograms daily) in older patients or those with cardiovascular disease
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Mizrahi, M., Adar, T., Lalazar, G., Nachman, D., El Haj, M., Yaacov, A
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doi: 10.1016/0014-5793(84)81114-X 17 CarlquistMMalettiMJrnvallHMuttV