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Transfection of Cyp2E1 [145] or induction of Cyp2E1 by dimethyl sulfoxide (DMSO) [139], can restore at least in part the metabolic capacity of HepG2 cells but the overall gene expression profile of HepG2 cells shows low similarity to primary human hepatocytes [146, 147]

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This multinational, multicentre, observational cohort study describes common clinical management and clinical outcomes related to bipolar disorders in real-life settings in contrast to published randomized clinical trials with strict inclusion and exclusion criteria