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A peptide that produces a strong GH response but also disrupts other hormones may create more problems than it solves if those secondary effects are not being tracked
In the SUSTAIN-6 trial, semaglutide was associated with a significant increased risk of diabetic retinopathy complications, including vitreous hemorrhage, blindness, or conditions requiring treatment with an intravitreal agent or photocoagulation (HR 1.76, 95% CI 1.112.78) [27]
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