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In biochemical and cellular research models, IGF-1 LR3 interacts with the IGF-1 receptor (IGF-1R), initiating intracellular signalling cascades associated with growth factormediated pathways

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The math is simpler than it sounds once you see it

Expression of Ngn3 directs differentiating secretory progenitors toward endocrine fate, while expression of Neurod1 directs differentiating EEC progenitors toward EECs such as L-cells