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Lab trends should be reviewed with a healthcare provider who understands the patient's symptoms, medications, and health history
If patients experience intolerable side effects at a given dose, maintaining the current dose for an additional 4 weeks or temporarily reducing the dose may improve tolerance before attempting further escalation
Evidence suggests estrogen modulates GLP-1 receptor expression in hypothalamic appetite centers
These can lead to insulin resistance, hypertension, joint pain, water retention, and potential cardiovascular or cancer risks
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