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Animal-model evidence consistently shows local effects: angiogenesis at the injury site (VEGF upregulation), growth-factor signaling (EGF, FGF), nitric oxide pathway modulation, and accelerated tendon-to-bone interface healing in rat Achilles transection studies

This is the longest nerve in your body, running from your lower back down each leg to your feet

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For people struggling with overeating, it can be therapeutic, but sexuality depends on that same dopaminergic motivation pathway