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However, the NAC monotherapy arm (600 mg three times daily) showed a trend toward slower decline in forced vital capacity (FVC) that did not reach statistical significance compared to placebo (Martinez et al., N Engl J Med, 2014) [45]

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X(PC), but not BoNT/X protease, cleaved full-length coatomer subunit alpha (COP), desmoglein-3 (DSG3), Rho guanine nucleotide exchange factor 2 (ARHG2), TF65, EIF3J, and CLSPN