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July 16 Product: Orexos OX124 Indication: Opioid overdose Second time is not the charm for Orexo, as the FDA denied its application for OX124, a high-dose naloxone nasal spray for the rescue treatment for opioid overdose

*Correspondence: Antonio Di Sabatino, [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Semaglutide, by contrast, is approved for chronic long-term use

GIP Activity GIP activity may add further metabolic effects

Common side effects include nausea, vomiting, diarrhea, and mild stomach discomfort