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Melanocortin-4 receptor agonism in hypothalamic circuits combined with melanocortin-3 receptor activity in the limbic system
GLP-1 receptor agonists like semaglutide and tirzepatide have transformed the treatment of type 2 diabetes and obesity
Within these preclinical frameworks, particular attention has been given to how distinct receptor pathways contribute to pulsatile growth hormone release and how parallel signaling inputs are integrated at the level of pituitary somatotrophs
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