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Whether liver-specific GSH synthesis was responsible for downregulated lipogenic gene expression and reduced serum triglycerides or whether these phenotypes were a byproduct of a liver-independent process in Gclc KO mice was unclear

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Data from other groups and our recent study have shown that endothelium and cardiac and vascular myocytes express a functional GLP-1R, and participate in the protective cardiovascular effects of GLP-1 analogues 11,36,37,38

Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE (1995) Metabolic effects of metformin in non-insulin-dependent diabetes mellitus

Exenatide was more effective for quitting smoking than a placebo after six weeks After six weeks, 46% of people taking exenatide had quit smoking compared to 27% of people taking a placebo