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Before reconstitution, keep vials at -20 degrees Celsius (-4 degrees Fahrenheit) for long-term storage, or 2 to 8 degrees Celsius (35.6 to 46.4 degrees Fahrenheit) for shorter periods

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2-4 weeks Skin feels smoother and better hydrated 4-8 weeks Firmness and tone start to look more even 3+ months Deeper, more lasting changes as collagen rebuilds Administration If your skin gets irritated, red, itchy, or flaky, stop using the cream and let your provider know

Pharmaceutical references and community sources describe this as the standard that requires no refrigeration and maintains the full manufacturer-printed shelf life