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(2020), iftci and Tuna (2021), Ng et al
As with other incretin-based therapies, the most commonly reported adverse effects of retatrutide in Phase 2 trials were gastrointestinal in nature (Jastreboff et al., NEJM , 2023)
On the other hand, in vitro experiments demonstrated that GLP-1RA morroniside could act directly on primary microglia, and promote the mRNA levels of the M2 microglial cell markers Agr1, C206, IL-4, and IL-10
Anti-inflammatory role: Reduces NF-B activation and pro-inflammatory cytokines
