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Both NAD and B12 are talked about for energy, but they act on different systems

Mouse research suggests that NNMT inhibition can change energy use inside cells, and an eight-week study in aged mice found better grip strength

Candidates were excluded if they had a history of a neurological disorder that may better explain the results of the study such as epilepsy, brain trauma, neuropsychiatric disorder or mild cognitive impairment

They're frequently studied together because their receptor pathways complement each other well, making them a natural pairing for researchers looking at how these two systems interact

PMID 25945462