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Similarly, activation of mitochondrial CB 1 Rs with THC resulted in reduced glycolytic activity and lactate production in primary cultured astrocytes (01-days-old), which was hypothesized to contribute to the subsequent impaired neuronal function and altered behavior (e.g., social interaction deficit) in young adult (812-weeks-old) mice (Jimenez-Blasco et al., 2020)
In addition, preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal (HPG) axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, concern new aspects in PCOS which are probably not always related to weight loss
Can the MTHFR gene mutation cause autoimmune disorders
The agency is investigating these adverse effects
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