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The mechanism: tirzepatide lowers insulin resistance, and high insulin secretion is regarded as a driver of follicle miniaturization, partly through stronger androgen signaling and more DHT production
The rate of loss slowed somewhat in the later weeks as a new energy balance was approached, but the trajectory had not leveled off by week 48
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[2] However, findings suggest that the majority of individuals that start a GLP-1 do not take the medication for the recommended 12 weeks, suggesting they are not achieving clinically meaningful weight loss.[2] Currently, 1 in 8 American adults have used one of the GLP-1 drugs and at least 30% ceased before 4 weeks, likely due to gastrointestinal distress.[2] Additionally, it is reported that there were over 25,000 emergency room visits between 2022-2023 due to GLP-1 use
