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The FDA approved the use of semaglutide as an adjunct for weight management in individuals without diabetes, but only when used in conjunction with other weight-loss measures and with a doctor's supervision
The FDA updated both the Mounjaro and Zepbound labels in November 2024 to add pulmonary aspiration during elective procedures as a postmarketing adverse reaction, and the UK MHRA issued a corresponding Drug Safety Update on the same concern
Some GLP-1 medicines are available as oral tablets, but only for diabetes treatment
The anti-obesity contract manufacturing process requires specific infrastructure demand, such as facility adaptation to assist those manufacturers of sterile injectables, the capability of handling anti-obesity API manufacturers, GMP compliance for weight-loss drugs manufacturing, and cold chain liability
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