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In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]
The remaining 3 studies, scored eight and nine, indicating high-quality studies with low risk of bias (Table 5)
In ex vivo and in vitro research, AHK-Cu was shown to stimulate human hair follicle growth and support dermal papilla cell activity, which plays an important role in the hair growth cycle
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