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In compounds 27 and 28 , the 1,4-dioxin group was replaced with phenol, the isopropyl acetate linkage was replaced with amine and amide, respectively, and the benzyl ring of the 2,3-dihydrobenzodioxin groups was replaced with 6-fluoro and 5,6-difluoro substitutions, respectively
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Evaulation of symptoms and symptom combinations in histamine intolerance
cDNA microarray analysis of rat Achilles tendon fibroblasts identified the growth hormone receptor as one of the most abundantly up-regulated genes following exposure to the peptide, with concentration- and time-dependent increases confirmed at both mRNA and protein level, and downstream Janus kinase 2 activation observed on subsequent growth hormone stimulation [3]
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