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Upon GLP-1R knockdown, additional signaling pathways beyond GLP-1 are involved to regulate LS GLP-1R neuronal activity and energy homeostasis

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This approach mirrors how anti-obesity medications are used in clinical practice, where long-term maintenance therapy prevents weight regain

Preserving muscle mass during rapid weight loss Retatrutide produces some of the most aggressive weight loss numbers ever documented in clinical trials

Therefore, the therapeutic potential of lactate and lactate-producing bacterial community extends beyond their direct actions, lying significantly in their capacity to nourish a cooperative microbial network through cross-feeding, which collectively stabilizes gut homeostasis and immune function