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In this review, we will summarize the state of art on this topic, overview the key unresolved questions that have emerged on the pharmacological targeting of these enzymes and their products, and highlight the need for further studies to ascertain the severity and duration of the adverse effects of 5-R inhibitors, as well as their biological underpinnings
Alternatives the physician considered, including the option of no treatment
Ferroptosis significantly contributes to the development and progression of T2D
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Cysteine availability determines or limits this synthesis
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