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Semaglutide dosing follows a gradual escalation schedule that starts at 0.25mg weekly and increases over 16-20 weeks to the maintenance dose

Consider electrolyte supplementation, particularly sodium, potassium, and magnesium, to maintain proper hydration balance

Trimethylamine N-oxide (TMAO) has emerged as a gut-derived metabolite of particular interest due to its association with multiple cardiovascular diseases 9,10,11,12

A recent study investigating the degree of therapeutic inertia associated with the prescription of GLP-1 RAs in primary care in the UK found that 54.9% of people with diabetes had an HbA 1c level of 75 mmol/mol (9.0%) at first prescription of subcutaneous semaglutide, which is in keeping with baseline characteristics of our cohort [23]

After washing, the membranes were incubated for 1 h with horseradish peroxidase-labeled secondary antibodies