The EXSCEL trial (Bethel et al., 2020) and LEADER trial (Marso et al., 2016) investigated the effect of exenatide and liraglutide, respectively, on microvascular and cardiovascular outcomes in patients with type 2 diabetes
No established medical contraindication exists for using GLP-1 receptor agonists in patients with Hashimoto's thyroiditis
Baicalein, another important flavonoid, demonstrates significant cardioprotective effects through activation of the Nrf2 signaling pathway, thereby attenuating the oxidative stress damage caused by tert-butyl hydroperoxide in H9C2 cardiomyocytes
C57BL/6J Vgat-ires-cre knock-in mice were purchased from The Jackson Laboratory (028862) and crossed with C57BL6/J Gipr flx/flx mice 35,36 to generate Vgat-cre +/ Gipr flx/flx ( Vgat-Gipr KO) mice and Vgat-cre +/ Gipr wt/wt (WT) controls
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