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The Potential Role of Glucagon-Like Peptide-1 (GLP-1) Agonists for Polycystic Ovary Syndrome

Viral-Hijacked Human Furin SARS-CoV-2, the etiological agent of COVID-19 pandemic, contains a unique insertion of amino acids (AAs), exclusively proline- arginine -arginine-alanine- arginine (P R RA R 685 ) at the S1/S2 boundary of its S-protein, which is clearly absent in SARS-CoV and other related hCoVs 72

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Table I [i] ROS reactive oxygen species, O 2 superoxide radical, mtDNA mitochondrial DNA, 8OHdG 8-hydroxy-2-deoxyguanosine, UCP2 uncoupling protein 2, CYP2E1 cytochrome P450 2E1, NOX NADPH oxidase, MDA malondialdehyde, 4-HNE 4-hydroxynonenal, TGF- transforming growth factor-, H 2 O 2 hydrogen peroxide