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There is consistent evidence from RCTs and real-world studies that SGLT2i use in type 1 diabetes is associated with an increased risk of DKA [14]
Patients prescribed GLP-1 receptor agonists can take several evidence-based steps to minimize any potential risks to their vision while maximizing the metabolic benefits of these medications
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TSH, free T4, and thyroid ultrasound at baseline and at 6-month intervals is a reasonable monitoring schedule
GLP-1(7-36) can suppress glucagon secretion in cells by increasing cAMP levels, activating PKA and EPAC, leading to a decrease in intracellular calcium concentration and reduced glucagon release
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