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Yang L, Tian S, Chen Y, Miao C, Zhao Y, Wang R, et al
Tsoli M, Chronaiou A, Kehagias I, Kalfarentzos F, Alexandrides TK
The Arg3 to Leu3 substitution disrupts a key contact residue in the IGFBP binding interface, and the N-terminal extension further sterically interferes with binding pocket access
Tirzepatide nausea typically peaks in week 23 and resolves by week 812 for most patients
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