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In hypoxic conditions, the additional post-translational stabilization of HIF1A, resulting from hydroxylase inhibition, leads to increased DNA-binding activity

Dr Jastreboff notes that mild to moderate gastrointestinal side effects are possible

The SUV value for the timeframe 5060 min after administration (SUV 55min ) provided the optimal contrast between liver tissue uptake (retention with time) and blood (clearance over time)

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