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Tendon and connective tissue repair research: Examining fibroblast proliferation, collagen synthesis, and FAK pathway activation in preclinical musculoskeletal injury models
doi:10.3390/ijms231911078 10
In preclinical studies, BPC-157 demonstrated an exceptionally wide therapeutic window with no observed toxicity even at high doses. Sikiric et al., Current Pharmaceutical Design Long-Term Safety As of now, long-term human safety data is lacking
Moreover, since at the time of diagnosis, 50% of patients presents metastases, 29% local/regional spread, and only 3% pancreatic carcinoma in situ, less than 15% of patients are eligible for surgical resection, compromising research efforts for inadequate number of available human samples [9,10,11, 13, 14]
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