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Discontinuation rates: Semaglutide has a meaningfully better tolerability profile
In patients with type 2 diabetes, treatment with semaglutide resulted in the following relative reductions in glucagon compared to placebo, fasting glucagon (8%), postprandial glucagon response (14-15%), and mean 24 hour glucagon concentration (12%)
These symptoms typically emerge during dose titration and may diminish over time as tolerance develops
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